The protein tyrosine phosphatase 1b as a drug target for the treatment of diabetes type II. Developing effective and selective PTP1B inhibitors

PTP1B is a protein tyrosine phosphatase involved in insulin receptor desensitization. PTP1B inhibition, resulting in prolonged maintenance of the activated state of the receptor, practically enhances insulin effect. Thus PTP1B has become a drug target for the treatment of Diabetes type II. Although, a great number of inhibitors have been developed, among which inhibitors binding to the catalytic site and allosteric inhibitors, development of novel highly effective and selective compounds based on profound knowledge of the structural characteristics of the binding sites and inhibitors still remains a challenge.